Oral Sildenafil in the Treatment of Erectile Dysfunction

Keep a list of them to show to your healthcare provider and pharmacist when you get a new medicine. Other drugs may interact with sildenafil, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Attribute	Description	Notes
Active Ingredient	Sildenafil citrate	50 mg per tablet
Mechanism of Action	PDE5 enzyme inhibition to promote vasodilation	Enhances blood flow for erectile function
Onset of Action	30-60 minutes	Varies with food intake
Duration of Effect	Up to 4-6 hours	Effect duration can vary
Metabolism	Primarily processed in the liver through CYP3A4 and CYP2C9 enzymes	Potential drug interactions
Contraindications	Use with nitrates or contraindicated in severe cardiovascular conditions	Precautions required

Store sildenafil tablets and oral film at room temperature, between 20°C and 25°C (68°F and 77°F).

• Sildenafil can cause side effects like dizziness.
• Use with caution if you have liver or kidney issues.
• The medication may cause vision changes or blurriness.
• Take sildenafil on an empty stomach for quicker effect.
• Follow your doctor’s dosage instructions strictly.
• Overdose may lead to serious health complications.
• Avoid driving or operating machinery after taking.
• Use only the prescribed strength, 50 mg.

Store sildenafil reconstituted oral suspension below 30°C (86°F) or in a refrigerator between 2°C to 8°C (36°F to 46°F). Throw away the reconstituted oral suspension after 60 days.

What special dietary instructions should I follow?

Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite ("poppers"). Taking sildenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure Alpha-blockers are sometimes prescribed for prostate problems orhigh blood pressure. In some patients, the use of sildenafil with alpha-blockers can lead to a drop in blood pressure or fainting Other drugs to treat high blood pressure or a prostate disorder Medicines to treat HIV, such as protease inhibitors, such as ritonavir and saquinavir Some types of oral antifungal medicines, such as ketoconazole and itraconazole Some types of antibiotics, such as erythromycin Other medicines that treat high blood pressure Medicines or treatments for ED, such as avanafil (Stendra), tadalafil (Cialis), or vardenafil (Levitra). Tell your doctor about all other medications you use for erectile dysfunction. Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure. Active ingredient: sildenafil citrateInactive ingredients: dextrose and water for injection. Contains no ingredients made from gluten-containing grain (eg, wheat, barley, or rye). Revatio is distributed by Pfizer Labs, Division of Pfizer Inc., NY, NY 10017.

• Sildenafil 50 mg tablets should be stored away from moisture.
• Do not alter the dosage prescribed by your doctor.
• Men with optic conditions should exercise caution.
• Be aware of the risk of sudden hearing loss.
• Use only as directed by healthcare providers.
• Keep track of medication expiration dates.
• The drug works best when taken on an empty stomach.
• Always inform your doctor of any new symptoms.

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Sildenafil is a medication used to treat erectile dysfunction which is effective and generally well-tolerated. There are a few potential side effects to be aware of, including headaches, nausea, and dizziness. These are fairly uncommon, but if you are struggling with them you should speak to your clinician. But like any other medication, it needs to be taken exactly as your doctor or pharmacist has instructed. Sildenafil works by allowing your arteries to relax and open, by making more of a chemical called cGMP available. Increasing blood flow through the arteries in the penis means improved erectile function. Cells in your arteries normally release nitric oxide, which, via molecular messengers including cGMP, sends instructions to muscle proteins to relax. This causes increased blood flow into your penis, which causes an erection. An enzyme called PDE-5 normally breaks down that cGMP, which reverses that relaxation, allowing your erection to subside. Sildenafil, a PDE-5 inhibitor, helps maintain that erection instead. There are some situations where you should not take sildenafil.

Adverse Effects

Avoid using any other medicines to treat impotence, such as alprostadil or yohimbine, without first talking to your doctor. Tell your healthcare provider about all the medicines you take, including prescription and over-the-countermedicines, vitamins, and herbal supplements. Sildenafil may affect the way other medicines work, and other medicines may affect the way sildenafil works, causing side effects. Especially tell your healthcare provider if you take: Nitrates for chest pain or heart problems. This includes nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate. You’re taking medications known as nitrates You’re taking medications known as nitrates You’re taking amyl nitrites (also known as “poppers”) You’re taking amyl nitrites (also known as “poppers”) You’re taking medications known as protease inhibitors You’re taking medications known as protease inhibitors You’re taking medications known as alpha-blockers You’re taking medications known as alpha-blockers You’re already taking sildenafil or any other PDE5 inhibitor in another form You’re already taking sildenafil or any other PDE5 inhibitor in another form You have any heart, liver or kidney problems You have any heart, liver or kidney problems You are taking medications for pulmonary arterial hypertension You are taking medications for pulmonary arterial hypertension You’re under the age of 18 You’re under the age of 18 The recommended starting dose is 50 mg.

What other information should I know?

Do not take more than once a day. If you take too much sildenafil, call your healthcare provider or go to the nearest hospital emergency room right away. Do not remove the film from the pouch unless ready for immediate use. Do not handle the oral film with wet hands. See the Vybrique Prescribing Information for more information about how to take sildenafil oral film.

Pregnancy Categories

Take sildenafil exactly as it was prescribed for you. Follow all directions on your prescription label and read all medication guides or instruction sheets. Do not change your dose or stop taking this medicine on your own. Take sildenafil tablet or oral suspension 3 times a day, about 4 to 6 hours apart. Take at approximately the same times every day. You shouldn’t take this more than once within a 24 hour period. Taking it more than once a day will increase the chance of side effects. If, after taking sildenafil, you feel the effect is too strong or too weak, you should talk to your doctor or pharmacist who may suggest an adjusted dosage for you or an alternative treatment. You should not take sildenafil film-coated tablets in combination with sildenafil oro-dispersible tablets. Take your sildenafil about an hour before you plan to have sex. Swallow the tablet whole with a glass of water.

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Sildenafil oral suspension will be mixed for you by sildenafil generic your pharmacist. Do not mix with other medicines or flavorings. Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). When sildenafil is used for ED, it is used as needed, so you are not likely to miss a dose.

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If you are taking sildenafil for PAH and you miss a dose, take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. If you take too much sildenafil, call your doctor or go to the nearest hospital emergency room. Drinking alcohol with sildenafil can cause side effects. Grapefruit juice and products may interact with sildenafil, leading to unwanted side effects. You can take it with or without food, but you might find that the effect takes longer to start if you’ve eaten heavily. Alcohol can interfere with your ability to get an erection (we’ve written about it in detail here), so to maximise the benefit of sildenafil, it’s best to give the beer a miss.

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Sildenafil is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Women with pulmonary arterial hypertension should not stop taking sildenafil without talking to their doctor if they discover they are pregnant. It is not known whether sildenafil passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breastfeeding a baby.

Oral Administration

Women with pulmonary arterial hypertension should not stop taking sildenafil without talking to their doctor. Take sildenafil oral tablets exactly as your healthcare provider tells you to take it. Your healthcare provider will tell you how much to take and when to take it. Your healthcare provider may change your dose if needed. You may take sildenafil between 30 minutes to 4 hours before sexual activity if needed. Grapefruit juice may increase the incidence of unwanted side effects of sildenafil. The effects of sildenafil last approximately four hours, which means your erectile function is improved for four hours. The effects of sildenafil become evident when you are sexually stimulated or aroused.

Drug Interactions

If you take sildenafil after a high-fat meal (such as a cheeseburger and fries), sildenafil may take a little longer to start working. If you accidentally take too much sildenafil, call your doctor or go to the nearest hospital emergency room right away. Sildenafil can help you have an erection when sexual stimulation occurs. An erection will not occur just by taking a pill. During sexual activity, if you become dizzy or nauseated, or have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away.

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You could be having a serious side effect of sildenafil. Take sildenafil oral film (Vybrique) exactly as your healthcare provider tells you to take it. Your healthcare provider will tell you how much sildenafil to take and when to take it. Take sildenafil by mouth about 1 hour before sexual activity. You may take sildenafil between 30 minutes and 4 hours before sexual activity if needed. You should not have an erection for four hours - a prolonged and painful erection (priapism) is a surgical emergency, and you should seek urgent medical attention should this happen. Most people feel the effect of sildenafil in 45 minutes or so. You’ll need to have sexual stimulation or feel sexually aroused to get an erection.